--- a/chrome/browser/ui/views/frame/tab_strip_region_view.cc
+++ b/chrome/browser/ui/views/frame/tab_strip_region_view.cc
@@ -301,6 +301,9 @@ TabStripRegionView::TabStripRegionView(s
         l10n_util::GetStringUTF16(IDS_TOOLTIP_NEW_TAB));
     new_tab_button_->GetViewAccessibility().SetName(
         l10n_util::GetStringUTF16(IDS_ACCNAME_NEWTAB));
+    new_tab_button_->SetTriggerableEventFlags(
+        new_tab_button_->GetTriggerableEventFlags() |
+        ui::EF_MIDDLE_MOUSE_BUTTON);
   }
 
   reserved_grab_handle_space_ =
--- a/chrome/browser/ui/views/tabs/tab_strip.cc
+++ b/chrome/browser/ui/views/tabs/tab_strip.cc
@@ -83,6 +83,8 @@
 #include "components/tab_groups/tab_group_id.h"
 #include "components/tab_groups/tab_group_visual_data.h"
 #include "components/tabs/public/split_tab_id.h"
+#include "ui/base/clipboard/clipboard.h"
+#include "ui/base/clipboard/clipboard_constants.h"
 #include "ui/base/dragdrop/drag_drop_types.h"
 #include "ui/base/dragdrop/mojom/drag_drop_types.mojom.h"
 #include "ui/base/interaction/element_identifier.h"
@@ -2255,6 +2257,20 @@ void TabStrip::NewTabButtonPressed(const
     if (hover_card_controller_) {
       hover_card_controller_->PreventImmediateReshow();
     }
+    const ui::MouseEvent& mouse = static_cast<const ui::MouseEvent&>(event);
+    if (mouse.IsOnlyMiddleMouseButton()) {
+      ui::Clipboard* clipboard = ui::Clipboard::GetForCurrentThread();
+      CHECK(clipboard)
+          << "Clipboard instance is not available, cannot proceed with "
+             "middle mouse button action.";
+      std::u16string clipboard_text;
+      clipboard->ReadText(ui::ClipboardBuffer::kSelection,
+                          /* data_dst = */ nullptr, &clipboard_text);
+      if (!clipboard_text.empty()) {
+        controller_->CreateNewTabWithLocation(clipboard_text);
+      }
+      return;
+    }
   }
   controller_->CreateNewTab(NewTabTypes::NEW_TAB_BUTTON);
 }