diff --git a/man/systemd.network.xml b/man/systemd.network.xml
index 7dc447d0a7..b587573a5f 100644
--- a/man/systemd.network.xml
+++ b/man/systemd.network.xml
@@ -662,6 +662,9 @@ Table=1234</programlisting></para>
           number of dynamically created network interfaces with the same network configuration and
           automatic address range assignment.</para>
 
+          <para>If an empty string is specified, then the all previous assignments in both [Network] and
+          [Address] sections are cleared.</para>
+
           <xi:include href="version-info.xml" xpointer="v211"/>
         </listitem>
       </varlistentry>
diff --git a/src/network/networkd-address.c b/src/network/networkd-address.c
index e3bdc66c58..ad49793a16 100644
--- a/src/network/networkd-address.c
+++ b/src/network/networkd-address.c
@@ -1994,10 +1994,16 @@ int config_parse_address(
         assert(rvalue);
         assert(data);
 
-        if (streq(section, "Network"))
+        if (streq(section, "Network")) {
+                if (isempty(rvalue)) {
+                        /* If an empty string specified in [Network] section, clear previously assigned addresses. */
+                        network->addresses_by_section = ordered_hashmap_free_with_destructor(network->addresses_by_section, address_free);
+                        return 0;
+                }
+
                 /* we are not in an Address section, so use line number instead. */
                 r = address_new_static(network, filename, line, &n);
-        else
+        } else
                 r = address_new_static(network, filename, section_line, &n);
         if (r == -ENOMEM)
                 return log_oom();
diff --git a/test/test-network/conf/25-address-static.network.d/20-clear-addresses.conf b/test/test-network/conf/25-address-static.network.d/20-clear-addresses.conf
new file mode 100644
index 0000000000..a38b07c1fb
--- /dev/null
+++ b/test/test-network/conf/25-address-static.network.d/20-clear-addresses.conf
@@ -0,0 +1,6 @@
+# SPDX-License-Identifier: LGPL-2.1-or-later
+
+[Network]
+# An empty string clears previously configured addresses.
+Address=
+Address=10.4.0.1/16
diff --git a/test/test-network/systemd-networkd-tests.py b/test/test-network/systemd-networkd-tests.py
index adb60cd489..6af6e6dc10 100755
--- a/test/test-network/systemd-networkd-tests.py
+++ b/test/test-network/systemd-networkd-tests.py
@@ -1087,7 +1087,7 @@ class NetworkctlTests(unittest.TestCase, Utilities):
         self.assertNotIn('dummy98', output)
 
     def test_reconfigure(self):
-        copy_network_unit('25-address-static.network', '12-dummy.netdev')
+        copy_network_unit('25-address-static.network', '12-dummy.netdev', copy_dropins=False)
         start_networkd()
         self.wait_online(['dummy98:routable'])
 
@@ -1121,7 +1121,7 @@ class NetworkctlTests(unittest.TestCase, Utilities):
         self.assertNotIn('inet 10.1.2.4/16 brd 10.1.255.255 scope global secondary dummy98', output)
         self.assertNotIn('inet 10.2.2.4/16 brd 10.2.255.255 scope global dummy98', output)
 
-        copy_network_unit('25-address-static.network')
+        copy_network_unit('25-address-static.network', copy_dropins=False)
         networkctl_reload()
         self.wait_online(['dummy98:routable'])
 
@@ -1154,7 +1154,7 @@ class NetworkctlTests(unittest.TestCase, Utilities):
             check()
 
     def test_up_down(self):
-        copy_network_unit('25-address-static.network', '12-dummy.netdev')
+        copy_network_unit('25-address-static.network', '12-dummy.netdev', copy_dropins=False)
         start_networkd()
         self.wait_online(['dummy98:routable'])
 
@@ -2756,6 +2756,15 @@ class NetworkdNetworkTests(unittest.TestCase, Utilities):
         for i in range(1, 254):
             self.assertIn(f'inet 10.3.3.{i}/16 brd 10.3.255.255', output)
 
+        # test for an empty string assignment for Address= in [Network]
+        copy_network_unit('25-address-static.network.d/20-clear-addresses.conf')
+        networkctl_reload()
+        self.wait_online(['dummy98:routable'])
+        output = check_output('ip -4 address show dev dummy98')
+        for i in range(1, 254):
+            self.assertNotIn(f'inet 10.3.3.{i}/16 brd 10.3.255.255', output)
+        self.assertIn('inet 10.4.0.1/16 brd 10.4.255.255', output)
+
     def test_address_ipv4acd(self):
         check_output('ip netns add ns99')
         check_output('ip link add veth99 type veth peer veth-peer')
@@ -3186,7 +3195,7 @@ class NetworkdNetworkTests(unittest.TestCase, Utilities):
         output = check_output(*networkctl_cmd, '--json=short', 'status', env=env)
         check_json(output)
 
-        copy_network_unit('25-address-static.network')
+        copy_network_unit('25-address-static.network', copy_dropins=False)
         networkctl_reload()
         self.wait_online(['dummy98:routable'])